#104- What Brain Surgery Teaches You About Living with Dr. Randy D'Amico

May 27, 2025

MORE ON THIS EPISODE

Renowned neurosurgeon at Lenox Hill Hospital Dr. Randy D'Amico is here to talk about one of the most high-pressure careers on the planet. After going viral on TikTok with his "day in the life of a neurosurgeon" videos, Dr. D'Amico opens up about what it's really like to perform brain surgery and how years of working on the human brain have shaped his perspective on life.

What You'll Learn:

Brain Health & Nutrition:

  • The neurosurgeon's daily diet for optimal brain function (avocado toast, Greek yogurt with chia seeds, and why he limits coffee)

  • Which supplements actually work (hint: only one made his list)

  • How alcohol really affects your brain and readiness scores

  • Natural ways to protect and strengthen your brain

Life & Career Insights:

  • How Dr. D'Amico went from punk rock musician to brain surgeon

  • What it's like to perform 15-hour surgeries and awake brain operations

  • His philosophy on handling pressure when lives are literally in your hands

  • Why "your brain is just mushy yellow tofu" - and what that means for how we experience reality

Practical Advice for Young Guys:

  • The "check your own pulse first" technique for staying calm under pressure

  • How to process difficult conversations and setbacks

  • Why reading books expands your beliefs and experiences

  • His controversial advice to his younger self

Key Takeaways:

Dr. D'Amico reveals how witnessing mortality daily has taught him that "life is a gift and none of us are owed anything." He shares intimate stories from the operating room, explains why he wakes up at 4:30 AM everyday, and discusses how he balances being a father of two while literally saving lives.

From his curated Spotify playlist "Great Songs" (featuring everything from Dead Kennedys to Taylor Swift) that he listens to during surgery, to his thoughts on social media's impact on young people's happiness, this conversation covers the intersection of medicine, mindset, and modern life.

Guest: Dr. Randy D'Amico - Neurosurgeon at Lenox Hill Hospital, TikTok creator, and author of the Spotify playlist "Great Songs"

Recorded live at Lenox Hill Hospital in New York City

More: What performing brain surgery teaches us about handling pressure, protecting our health, and finding perspective in life

Introduction

What does it take to perform brain surgery? How do you stay calm when someone's life is literally in your hands? In a recent episode of Guyset, we sat down with Dr. Randy D'Amico, a neurosurgeon at Lenox Hill Hospital, to explore one of the highest-pressure jobs on the planet and the profound life lessons it teaches.

Dr. D'Amico's journey from punk rock musician to brain surgeon offers unique insights into handling pressure, protecting our mental health, and finding meaning in our daily lives. Here's what we learned about thriving under pressure and optimizing our brains for peak performance.

The Daily Life of a Neurosurgeon: Extreme Discipline

Morning Routine That Sets the Tone

Dr. D'Amico's day starts at 4:30 AM with a routine that would impress any productivity guru:

  • 4:30 AM: Wake up (often before his alarm)

  • 5:00 AM: Arrive at hospital, handle emails

  • 5:30 AM: 40-minute gym session using Apple Fitness

  • 6:30-8:00 AM: Focused work time with zero interruptions

  • 7:45 AM: Operating room (on surgery days)

"I am immediately awake," he explains. "Sometimes I'm awake before my alarm because I anticipate it." This level of discipline isn't just about productivity—it's about preparation for life-and-death decisions.

The Mental Game: Preparation and Visualization

Before major surgeries, Dr. D'Amico employs techniques that any high-performer can apply:

  1. Mental Rehearsal: "I will spend time going in my head - what the incision is going to look like, how the bone is going to come off, what do I expect to see based on stuff I've done in the past."

  2. Technology-Assisted Preparation: Using augmented reality systems to rotate 3D brain models and review MRI scans

  3. Systematic Planning: Identifying "no-fly zones" and safe areas before entering the operating room

The lesson for the rest of us? Preparation isn't just helpful—it's everything. "When problems happen, it's because you didn't take that time and go over it."

Brain Health: What a Neurosurgeon Actually Does

Daily Nutrition for Optimal Brain Function

Dr. D'Amico's approach to eating is both scientific and practical:

Morning Foundation:

  • Avocado toast on seedy, low-glycemic bread

  • Hot sauce for flavor and metabolism benefits

Mid-Morning Fuel:

  • Two Greek yogurts with chia seeds and hemp seeds

  • Focus on protein with minimal carbs

Afternoon Strategy:

  • Peanut butter on quality toast for sustained energy

  • Green tea instead of excessive coffee

Evening Approach:

  • Low-glycemic pasta (when possible)

  • Abundant vegetables, especially leafy greens

  • Natural, whole foods prioritized over processed options

The Science Behind His Choices

"I became obsessed with a glucometer for a period of time. I was just watching my glucose trends and trying to flatten the curve," he explains. This data-driven approach to nutrition focuses on:

  • Maintaining stable blood sugar levels

  • Supporting sustained energy throughout long surgeries

  • Optimizing heart rate variability for better stress management

Supplements That Actually Matter

In a world flooded with supplement marketing, Dr. D'Amico keeps it simple:

Creatine: "There's enough scientific backing on it. There's the brain health component and the muscle recovery component."

Magnesium: For improved sleep quality (after discovering melatonin caused grogginess and strange dreams)

That's It: "Supplements are tricky because they're not FDA regulated. You have to be really careful."

What Brain Surgery Teaches About Life

Perspective on Mortality and Meaning

"Life is a gift and none of us are owed anything at all," Dr. D'Amico reflects. "Brain tumors and spine tumors and any sort of cancers, accidents—they don't give a shit who you are. We treat celebrities, we treat homeless people. The same disease affects all humans."

This daily confrontation with mortality provides profound perspective:

  • Every day is borrowed time: The fragility of life becomes visceral when you see how quickly everything can change

  • Status doesn't matter: Disease and injury are the great equalizers

  • Stories matter more than procedures: "Every story is so fascinating to me... one million individual stories and one million individual responses"

The Philosophy of Crisis Management

When complications arise in surgery, Dr. D'Amico follows a principle that applies to any high-stress situation:

"Check your own pulse first."

The framework for handling any crisis:

  1. Stay Calm: "If you panic, everyone panics"

  2. Pause and Think: "You have to stop and pause and think back to your training"

  3. Take Control: Clear, direct communication about next steps

  4. Regroup: Systematic reassessment and reorganization

"In the operating room, especially in those situations, I am middle of ground. I am just there. I'm zoned in."

The Substances That Help (and Hurt) Your Brain

What to Limit or Avoid

Alcohol: "If you look at people who have one [drink] the day after they drink, their readiness score just plummets. It really fucks with you."

Excessive Coffee: While not inherently bad, Dr. D'Amico noticed it affected his heart rate variability and switched to more green tea.

Vaping: "It has to be better than a cigarette, but it also has to be bad for you too."

What Might Help (With Caution)

Microdosing Psychedelics: "Psilocybin has a wealth of literature about the positive benefits... psychiatrists have been looking at this for years."

Medical Ketamine: For treatment-resistant depression in clinical settings

Cannabis: "There's no major issues with weed... anything becomes a problem when you become dependent on it."

The key principle: moderation and medical supervision for anything beyond basic nutrition and exercise.

Brain Optimization: Practical Strategies

Use It or Lose It

Dr. D'Amico's prescription for brain health is refreshingly simple:

  1. Read Books: "Reading a book expands your ideas... it takes you to a place that you are not in"

  2. Listen to Music Thoughtfully: "Think about why you like this or why you don't like this"

  3. Look at Art: "Just think about why you're looking at it and why someone made it"

  4. Challenge Yourself: "If you're using your brain, you're using your brain. That's a good thing."

The Fundamentals Never Change

Despite access to cutting-edge medical knowledge, Dr. D'Amico's advice centers on timeless principles:

  • Exercise regularly: Zone 2 cardio, strength training, functional movement

  • Prioritize sleep: "Sleep is super important. Everyone has proven that."

  • Eat natural foods: "What is natural is probably not wrong"

  • Use your brain: Continuous learning and cognitive challenges

The Bigger Picture: Evolution and Human Nature

Getting Back to Basics

"Put what you're doing in the context of humanity. Evolution created us from something and we are evolving... but at the bottom line is what is natural?"

Dr. D'Amico advocates for aligning our modern lives with our evolutionary blueprint:

  • Natural sleep patterns (early to bed, early to rise)

  • Whole food nutrition (avoiding processed foods)

  • Regular physical activity (as our ancestors required for survival)

  • Strong social connections (tribal community structures)

Perspective on Modern Challenges

"Everything that you see, every conversation that you have... it's just a piece of mushy, like medium tofu," he says, referring to the brain. "Such a delicate structure. And that's everything that we do."

This perspective offers profound humility about human achievement while emphasizing the importance of protecting and optimizing our neural hardware.

Lessons for Young Men

Handling Pressure and Expectations

Dr. D'Amico's advice for young men facing societal pressures:

"Shut up and listen to the other opinions and look at the other viewpoint... You will be a better man, a better human if you just appreciate humanity for being this diverse thing."

Building Resilience

Key principles from someone who handles life-and-death pressure daily:

  1. Preparation is everything: "As long as you do a little prep work, things go fine"

  2. Truth is your foundation: "Tell the truth because the truth is the truth. It's fact."

  3. Find your support systems: "You find your sources of comfort... you build that and you get used to it"

  4. Keep perspective: "There's no race, there's no rush, there's no timeline"

Actionable Takeaways

Immediate Changes You Can Make

  1. Morning Routine: Start your day with intention, even if you can't wake up at 4:30 AM

  2. Nutrition: Focus on whole foods, stable blood sugar, and adequate protein

  3. Supplements: Consider creatine and magnesium; skip the exotic stuff

  4. Preparation: Mentally rehearse important events or challenges

  5. Perspective: Remember that most daily stresses are temporary and fixable

Long-term Brain Health Strategy

  1. Read regularly: Expand your experiences through literature

  2. Exercise consistently: Both cardio and strength training

  3. Sleep prioritization: Quality sleep is non-negotiable

  4. Stress management: Develop systems for handling pressure

  5. Continuous learning: Keep challenging your brain with new skills and knowledge

Conclusion: The Wisdom of High-Stakes Medicine

Dr. Randy D'Amico's insights remind us that whether you're performing brain surgery or navigating daily challenges, the fundamentals remain the same: preparation, perspective, and taking care of your basic human needs.

His journey from punk rock musician to neurosurgeon proves that unconventional paths can lead to extraordinary contributions. More importantly, his daily practice of maintaining calm under extreme pressure offers valuable lessons for anyone looking to optimize their performance and find meaning in their work.

The next time you're stressed about a deadline, argument, or setback, remember: "There's no race, there's no rush, there's no timeline. The only thing you're racing towards is death." That perspective isn't morbid—it's liberating. It frees you to focus on what actually matters: taking care of your brain, showing up for the people you care about, and finding meaning in the daily practice of being human.

As Dr. D'Amico puts it: "Life is a gift." The question is: what are you going to do with yours?

For more insights on optimizing your health, career, and relationships in your twenties, subscribe to Guyset and join our community of young men committed to personal growth and authentic conversation.

Connect with Dr. Randy D'Amico:

  • Social Media: @RandyDAmico (all platforms)

  • Spotify Playlist: "Great Songs" by Randy D'Amico

Resources Mentioned:

  • "The Great Nerve" by Kevin Tracy

  • "Meditations" by Marcus Aurelius

  • "When Breath Becomes Air" by Paul Kalanithi

Connect with Guyset:

  • Instagram/TikTok: @theguyset

  • Email: josh@guyset.com

  • Website: guyset.com

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